SrasV1, France, Analysis, bibRecord, 000326

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

Identifieur interne : 000326 ( France/Analysis ); précédent : 000325; suivant : 000327

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

Auteurs : Marie-Pierre Egloff [France] ; Hélène Malet [France] ; Akos Putics [Allemagne] ; Maarit Heinonen [Finlande] ; Hélène Dutartre [France] ; Antoine Frangeui [France] ; Arnaud Gruez [France] ; Valérie Campanacci [France] ; Christian Cambillau [France] ; John Ziebuhr [Allemagne, Royaume-Uni] ; Tero Ahola [Finlande] ; Bruno Canard [France]

Source :

Journal of virology [ 0022-538X ] ; 2006.

RBID : Pascal:06-0412132

Descripteurs français

English descriptors

KwdEn :
- ADP, Adenosine Diphosphate Ribose (analogs & derivatives), Adenosine Diphosphate Ribose (chemistry), Adenosine Diphosphate Ribose (metabolism), Amino Acid Sequence, Crystallography, Hepatitis E virus (chemistry), Hepatitis E virus (metabolism), Histones (chemistry), Histones (metabolism), Microbiology, Models, Molecular, Molecular Sequence Data, Poly Adenosine Diphosphate Ribose (metabolism), Poly(ADP-ribose) Polymerases (metabolism), SARS Virus (chemistry), SARS Virus (metabolism), Semliki forest virus (chemistry), Semliki forest virus (metabolism), Structure-Activity Relationship, Virology.
MESH :
- chemical , analogs & derivatives : Adenosine Diphosphate Ribose.
- chemical , chemistry : Adenosine Diphosphate Ribose, Histones.
- chemical , metabolism : Adenosine Diphosphate Ribose, Histones, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases.
- chemistry : Hepatitis E virus, SARS Virus, Semliki forest virus.
- metabolism : Hepatitis E virus, SARS Virus, Semliki forest virus.
- Amino Acid Sequence, Crystallography, Models, Molecular, Molecular Sequence Data, Structure-Activity Relationship.

Abstract

Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.

Url:

https://hal.archives-ouvertes.fr/hal-02459228

Affiliations:

Links to Exploration step

Pascal:06-0412132

Le document en format XML

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<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisbum Rd</s1>
<s2>Belfast BT9 7BL</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Belfast BT9 7BL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADP</term>
<term>Adenosine Diphosphate Ribose (analogs & derivatives)</term>
<term>Adenosine Diphosphate Ribose (chemistry)</term>
<term>Adenosine Diphosphate Ribose (metabolism)</term>
<term>Amino Acid Sequence</term>
<term>Crystallography</term>
<term>Hepatitis E virus (chemistry)</term>
<term>Hepatitis E virus (metabolism)</term>
<term>Histones (chemistry)</term>
<term>Histones (metabolism)</term>
<term>Microbiology</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Poly Adenosine Diphosphate Ribose (metabolism)</term>
<term>Poly(ADP-ribose) Polymerases (metabolism)</term>
<term>SARS Virus (chemistry)</term>
<term>SARS Virus (metabolism)</term>
<term>Semliki forest virus (chemistry)</term>
<term>Semliki forest virus (metabolism)</term>
<term>Structure-Activity Relationship</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine diphosphate ribose ()</term>
<term>Adénosine diphosphate ribose (analogues et dérivés)</term>
<term>Adénosine diphosphate ribose (métabolisme)</term>
<term>Cristallographie</term>
<term>Données de séquences moléculaires</term>
<term>Histone ()</term>
<term>Histone (métabolisme)</term>
<term>Modèles moléculaires</term>
<term>Poly adénosine diphosphate ribose (métabolisme)</term>
<term>Poly(ADP-ribose) polymerases (métabolisme)</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Virus de l'hépatite E ()</term>
<term>Virus de l'hépatite E (métabolisme)</term>
<term>Virus de la forêt de Semliki ()</term>
<term>Virus de la forêt de Semliki (métabolisme)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
<term>Histones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
<term>Histones</term>
<term>Poly Adenosine Diphosphate Ribose</term>
<term>Poly(ADP-ribose) Polymerases</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hepatitis E virus</term>
<term>SARS Virus</term>
<term>Semliki forest virus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hepatitis E virus</term>
<term>SARS Virus</term>
<term>Semliki forest virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
<term>Histone</term>
<term>Poly adénosine diphosphate ribose</term>
<term>Poly(ADP-ribose) polymerases</term>
<term>Virus de l'hépatite E</term>
<term>Virus de la forêt de Semliki</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Crystallography</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>ADP</term>
<term>Adénosine diphosphate ribose</term>
<term>Cristallographie</term>
<term>Données de séquences moléculaires</term>
<term>Histone</term>
<term>Microbiologie</term>
<term>Modèles moléculaires</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Virologie</term>
<term>Virus de l'hépatite E</term>
<term>Virus de la forêt de Semliki</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Finlande</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Bavière</li>
<li>District de Basse-Franconie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
<li>Marseille</li>
<li>Wurtzbourg</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
</region>
<name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
<name sortKey="Frangeui, Antoine" sort="Frangeui, Antoine" uniqKey="Frangeui A" first="Antoine" last="Frangeui">Antoine Frangeui</name>
<name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
<name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
</country>
<country name="Allemagne"><region name="Bavière"><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
</region>
<name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</country>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
</region>
<name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

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